Baltic Pharmaceuticals Arimidex (Anastrozole) is a competitive aromatase inhibitor that blocks the conversion of testosterone to oestrogen, preventing water retention, bloating, elevated blood pressure, and gynecomastia during steroid cycles. It is considered an essential ancillary for any cycle that includes aromatising compounds such as Testosterone, Dianabol, or Deca-Durabolin. This product is manufactured by Baltic Pharmaceuticals and lab-tested for accurate dosing.
How Arimidex Works
When you inject testosterone or take aromatising oral steroids, a portion of the exogenous hormone is converted to oestradiol (E2) by the aromatase enzyme. At supraphysiological steroid doses, this conversion produces oestrogen levels far above the normal range, causing a cascade of unwanted effects: subcutaneous water retention that blurs muscle definition, blood pressure elevation from increased fluid volume, and the development of breast tissue (gynecomastia) in sensitive individuals.
Arimidex (Anastrozole) works by competitively binding to the aromatase enzyme, preventing it from converting androgens to oestrogen. According to pharmaceutical data, a single 1mg dose of Anastrozole reduces circulating oestradiol by approximately 70-80% within 24 hours. At the typical on-cycle dose of 0.25-0.5mg every other day, oestrogen is kept within a manageable range rather than being eliminated entirely.
Why Oestrogen Control Matters
Complete oestrogen suppression is counterproductive. Oestrogen plays important roles in joint health, lipid metabolism, bone density, and even muscle growth (it contributes to IGF-1 production). The goal is not to eliminate oestrogen but to keep it within a healthy range while running aromatising compounds. This is why bloodwork during a cycle is invaluable: a serum oestradiol test at mid-cycle tells you exactly whether your AI dose needs adjusting.
Signs of oestrogen running too high: water retention, puffy nipples, bloating, mood swings, elevated blood pressure. Signs of oestrogen crashed too low: dry joints, fatigue, low libido, depression, lethargy. Either extreme is undesirable.
Suggested Protocol
- Testosterone 300-500mg/week: 0.25mg every other day. Adjust based on symptoms or bloodwork
- Testosterone + Dianabol: 0.5mg every other day. Dianabol aromatises heavily and often requires a higher AI dose
- Low-dose TRT (100-200mg/week): 0.25mg twice per week or as needed. Many TRT users do not need an AI at all
- Start the AI on the same day you begin your cycle. Do not wait for side effects to appear before starting oestrogen control
- Taper off rather than stopping abruptly to avoid oestrogen rebound (competitive AI characteristic)
Arimidex vs Aromasin
Both are aromatase inhibitors but work differently:
- Arimidex (Anastrozole): competitive (reversible) AI. Binds to aromatase temporarily. If stopped abruptly, oestrogen can rebound as the enzyme becomes free again. Slightly harsher on lipid profiles
- Aromasin (Exemestane): suicidal (irreversible) AI. Permanently destroys the aromatase enzyme. No rebound risk. Slightly more lipid-friendly
- Both are effective. Arimidex is more widely available and commonly used. Aromasin may be preferred for longer cycles or users prone to oestrogen rebound
Key Facts
- Active ingredient: Anastrozole
- Manufacturer: Baltic Pharmaceuticals
- Class: Non-steroidal competitive aromatase inhibitor
- Half-life: approximately 46 hours
- Oestrogen reduction: 70-80% at 1mg/day
- Typical on-cycle dose: 0.25-0.5mg every other day
For a full breakdown of managing oestrogen and other cycle side effects, read our Steroid Side Effects Guide. For PCT protocols after your cycle, see our PCT Guide. Browse all cycle support products.



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